Cellular and molecular mechanisms of metformin: an overview.

@article{Viollet2012CellularAM,
  title={Cellular and molecular mechanisms of metformin: an overview.},
  author={Benoit Viollet and Bruno Guigas and Nieves Sanz Garcia and Jocelyne A. Leclerc and Marc Foretz and Fabrizio Andreelli},
  journal={Clinical science},
  year={2012},
  volume={122 6},
  pages={
          253-70
        }
}
Considerable efforts have been made since the 1950s to better understand the cellular and molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now recommended as the first-line oral therapy for T2D (Type 2 diabetes). The main effect of this drug from the biguanide family is to acutely decrease hepatic glucose production, mostly through a mild and transient inhibition of the mitochondrial respiratory chain complex I. In addition, the resulting decrease in hepatic energy… CONTINUE READING

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Differential effects of metformin glycinate and hydrochloride in glucose production, AMPK phosphorylation and insulin sensitivity in hepatocytes from non-diabetic and diabetic mice.

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  • 2019
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