Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice.

@article{Cariou2004CellularAM,
  title={Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice.},
  author={Bertrand Cariou and Catherine Postic and Philippe Boudou and Remy Burcelin and C Ronald Kahn and Jean Girard and Anne-Françoise Burnol and Franck Mauvais-Jarvis},
  journal={Endocrinology},
  year={2004},
  volume={145 4},
  pages={1926-32}
}
White adipose tissue (WAT) plays a critical role in the development of insulin resistance via secretion of free fatty acids (FFA) and adipocytokines. Muscle-specific insulin receptor knockout (MIRKO) mice do not develop insulin resistance or diabetes under physiological conditions despite a marked increase in adiposity and plasma FFA. On the contrary, WAT of MIRKO is sensitized to insulin action during a euglycemic clamp, and WAT glucose utilization is dramatically increased. To get insight… CONTINUE READING