Cellular and molecular mechanisms of HIV-1 integration targeting

Abstract

Integration is central to HIV-1 replication and helps mold the reservoir of cells that persists in AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior regions of transcriptionally active genes within gene-dense regions of chromatin. The viral capsid interacts with several proteins that are additionally implicated… (More)
DOI: 10.1007/s00018-018-2772-5

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