Cellular and molecular evidence for malignancy-inhibitory functions of p15RS

@article{Zhang2012CellularAM,
  title={Cellular and molecular evidence for malignancy-inhibitory functions of p15RS},
  author={Xiaocui Zhang and Qiuju Cao and Xiaodan Liu and Shuaishuai Liu and Juan Wang and Shenghuan Sun and Ou Wang and Zhihua Tian and Huitu Liu and Jian Kuang and Wei Zhang},
  journal={Cell Cycle},
  year={2012},
  volume={11},
  pages={1988 - 1998}
}
The gene for the INK4 family Cdk inhibitor p15INK4B is frequently deleted or inactivated in multiple types of human cancers, indicating that p15 is a tumor suppressor. p15RS is a ubiquitously expressed nuclear protein that is positively regulated by p15 and, in turn, inhibits the expression of cyclin D and cyclin E. To determine whether p15RS has malignancy inhibitory functions in addition to its inhibitory effects on cell cycle entry, we ectopically expressed p15RS in metastatic melanoma A375… Expand
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