Cellular and molecular evidence for malignancy-inhibitory functions of p15RS

  title={Cellular and molecular evidence for malignancy-inhibitory functions of p15RS},
  author={Xiaocui Zhang and Qiuju Cao and Xiaodan Liu and Shuaishuai Liu and Juan Wang and Shenghuan Sun and Ou Wang and Zhihua Tian and Huitu Liu and Jian Kuang and Wei Zhang},
  journal={Cell Cycle},
  pages={1988 - 1998}
The gene for the INK4 family Cdk inhibitor p15INK4B is frequently deleted or inactivated in multiple types of human cancers, indicating that p15 is a tumor suppressor. p15RS is a ubiquitously expressed nuclear protein that is positively regulated by p15 and, in turn, inhibits the expression of cyclin D and cyclin E. To determine whether p15RS has malignancy inhibitory functions in addition to its inhibitory effects on cell cycle entry, we ectopically expressed p15RS in metastatic melanoma A375… Expand
Targeting Cdk11 in osteosarcoma cells using the CRISPR‐cas9 system
  • Yong Feng, S. Sassi, +9 authors Z. Duan
  • Biology, Medicine
  • Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2015
It is demonstrated that CRISPR‐Cas9 system is a useful tool for the modification of endogenous CDK11 gene expression, and CRISpr‐ Cas9 targeted CDK 11 knockout may be a promising therapeutic regimen for the treatment of osteosarcoma. Expand
CREPT and p15RS regulate cell proliferation and cycling in chicken DF‐1 cells through the Wnt/β‐catenin pathway
CREPT and p15RS regulate cell proliferation and the cell‐cycle transition in chicken DF‐1 cells by regulating the transcription of Wnt/β‐catenin pathway downstream regulatory genes. Expand
CREPT/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the β-Catenin·TCF4 Transcriptional Activity in Response to Wnt Signaling*
The study suggests that CREPT acts as an activator to promote transcriptional activity of the β-catenin·TCF4 complex in response to Wnt signaling, which results in up-regulated cell proliferation and invasion. Expand
Dimerization of p15RS mediated by a leucine zipper–like motif is critical for its inhibitory role on Wnt signaling
  • Xuanzi Fan, Juan Zhao, +10 authors Z. Chang
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 2018
It is reported that dimerization of p15RS governed by the leucine zipper–like motif is critical for its inhibition of Wnt/β-catenin signaling and tumorigenesis. Expand
p15RS/RPRD1A (p15INK4b-related Sequence/Regulation of Nuclear Pre-mRNA Domain-containing Protein 1A) Interacts with HDAC2 in Inhibition of the Wnt/β-Catenin Signaling Pathway*
Background: p15RS/RPRD1A inhibits Wnt/β-catenin signaling by recruiting HDAC2. Results: p15RS interacts with HDAC2 and enhances the occupancy of HDAC2 to promoters of Wnt-targeted genes, keepingExpand
Current understanding of CREPT and p15RS, carboxy-terminal domain (CTD)-interacting proteins, in human cancers
Fully revealing the mechanisms of CREPT and p15RS functions will not only provide new insights into understanding gene transcription and maintenance of DNA stability in tumors, but also promote new approach development for tumor diagnosis and therapy. Expand
Structural basis for the recognition of RNA polymerase II C-terminal domain by CREPT and p15RS
It is proposed that dimerization through the C-terminal domain enhances the binding strength between CREPT or p15RS with Pol II by increasing binding avidity. Expand
A preliminary study of the effect of a high-salt diet on transcriptome dynamics in rat hypothalamic forebrain and brainstem cardiovascular control centers
These findings demonstrated the adverse effects of HS diet on BP, which may be mediated via modulating the signaling systems in CV centers in the hypothalamic forebrain and brainstem. Expand


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The genomic status of two recently isolated p16-related CDK inhibitors, p15 and p18, are examined in 15 normal and 73 tumor-derived cell lines established from 23 different tissues, as well as 26 invasive primary breast cancers and 20 acute myelogenous leukemias to indicate that mutation of the p18 gene occurs rarely in human tumors. Expand
p27 deficiency is associated with migration defects in PDGF-expressing gliomas in vivo
The results suggest that p27 mediated regulation of the Rho pathway is cell cycle independent and demonstrate for the first time a migration defect in cancer cells that is associated with p27 deficiency in vivo in a mouse tumor model. Expand
Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma.
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Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
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p27Kip1 modulates cell migration through the regulation of RhoA activation.
A novel role is suggested for p27(Kip1) in regulating cell migration via modulation of the Rho pathway through inhibition of ROCK and interference with the interaction between RhoA and its activators, the guanine-nucleotide exchange factors (GEFs). Expand
Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1.
The data reported here support a direct role for cyclin D1 and its associated kinase in cell cycle regulation of E2F activity and S phase-specific gene expression. Expand
RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas
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Molecular events involved in the increased expression of matrix metalloproteinase-9 by T lymphocytes of mammary tumor-bearing mice.
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Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells
The results strongly support a role for cathepsin B in the invasiveness of human glioblastoma cells and suggest cathePSin B antisense may prove useful in cancer therapy. Expand
Molecular analysis of the cyclin‐dependent kinase inhibitor genes p15INK4b/MTS21, p16INK4/MTS1, p18 and pl9 in human cancer cell lines
The hypotheses that either post‐translational modification or enhanced degradation may be responsible for the lack of detection of the pl6INK4/MTS1 protein are suggested. Expand