Cellular and molecular events leading to renal tubulointerstitial fibrosis

@article{Razzaque2002CellularAM,
  title={Cellular and molecular events leading to renal tubulointerstitial fibrosis},
  author={Mohammed Shawkat Razzaque and Takashi Taguchi},
  journal={Medical Electron Microscopy},
  year={2002},
  volume={35},
  pages={68-80}
}
 Connective tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic process associated with both physiological responses, such as wound healing, and pathological conditions, such as renal tubulointerstitial fibrosis (TIF). Data from the published literature indicate that collagens and several non-collagenous ECM glycoproteins actively contribute to TIF. The early phase of TIF is usually associated with an inflammatory process mediated by soluble factors released by… CONTINUE READING