Cellular and molecular effects of vitamin D on carcinogenesis.

  title={Cellular and molecular effects of vitamin D on carcinogenesis.},
  author={J Luckey Welsh},
  journal={Archives of biochemistry and biophysics},
  volume={523 1},
Epidemiologic data suggest that the incidence and severity of many types of cancer inversely correlates with indices of vitamin D status. The vitamin D receptor (VDR) is highly expressed in epithelial cells at risk for carcinogenesis including those resident in skin, breast, prostate and colon, providing a direct molecular link by which vitamin D status impacts on carcinogenesis. Consistent with this concept, activation of VDR by its ligand 1,25-dihydroxyvitamin D (1,25D) triggers comprehensive… CONTINUE READING