Cellular and molecular effects of resveratrol in health and disease

@article{Yu2012CellularAM,
  title={Cellular and molecular effects of resveratrol in health and disease},
  author={Wei Yu and Yu-cai Fu and Wei Wang},
  journal={Journal of Cellular Biochemistry},
  year={2012},
  volume={113}
}
Resveratrol, a natural polyphenol abundantly found in grape skins and red wine, possesses diverse biochemical and physiological actions, including anti‐inflammatory, anti‐oxidation, anti‐proliferation and promotion of differentiation, and chemopreventive effects. Recently, it is attracting increased attention due to its health benefits, especially in common age‐related diseases such as cardiovascular disease, cancer, type 2 diabetes, and neurological conditions. In this review, we discuss the… Expand
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References

SHOWING 1-10 OF 105 REFERENCES
Resveratrol: cellular actions of a potent natural chemical that confers a diversity of health benefits.
TLDR
More potent sirtuin activators have now been discovered by large-scale screening programs, and Resveratrol and the new compounds are the subject of clinical trials to determine their consumer safety and suitability for the prevention and treatment of most common diseases of aging. Expand
Resveratrol in prevention and treatment of common clinical conditions of aging
TLDR
The future bodes well for the use of resveratrol and analogues of higher potency than the natural form for treatment of diseases that afflict humans, particularly as they age. Expand
Therapeutic potential of resveratrol: the in vivo evidence
TLDR
A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered. Expand
Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications.
TLDR
Its strong anti-inflammatory activity and the plausible mechanisms of these effects are reviewed to provide the reader an up-date of the bioavailability and pharmacokinetics of resveratrol and its impact on lifespan. Expand
Beneficial effects of resveratrol on atherosclerosis.
TLDR
Beneficial effects of resveratrol on the initiation and progression of atherosclerosis, including regulation of vasodilator and vasoconstrictor production, inhibition of oxidative stress/reactive oxygen species generation, anti-inflammation, and its abilities to impede progression and modulate complications of Atherosclerosis are discussed. Expand
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
TLDR
It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans. Expand
Biological effects of resveratrol.
TLDR
Resveratrol has been shown to modulate the metabolism of lipids, and to inhibit the oxidation of low-density lipoproteins and the aggregation of platelets, and may play a role in the prevention of human cardiovascular diseases. Expand
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.
TLDR
It is demonstrated that resveratrol and quercetin have novel nonsteroidal anti-inflammatory activity that may have applications for the treatment of inflammatory diseases. Expand
Anti-inflammatory mechanisms of resveratrol in activated HMC-1 cells: pivotal roles of NF-kappaB and MAPK.
TLDR
Results indicated that resveratrol exerted a regulatory effect on inflammatory reactions mediated by mast cells. Expand
Mechanisms of cardiovascular protection by resveratrol.
TLDR
Resveratrol protects the cardiovascular system by mechanisms that include defense against ischemic-reperfusion injury, promotion of vasorelaxation, protection and maintenance of intact endothelium, anti-atherosclerotic properties, inhibition of low-density lipoprotein oxidation, suppression of platelet aggregation, and estrogen-like actions. Expand
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