Cellular and molecular characterization of Ca2+ currents in acutely isolated, adult rat neostriatal neurons.

@article{Bargas1994CellularAM,
  title={Cellular and molecular characterization of Ca2+ currents in acutely isolated, adult rat neostriatal neurons.},
  author={Jos{\'e} Bargas and Alan Howe and James Eberwine and Yu-qing Cao and D. James Surmeier},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1994},
  volume={14 11 Pt 1},
  pages={6667-86}
}
Ca2+ currents in acutely isolated, adult rat neostriatal neurons were studied with whole-cell voltage-clamp techniques. In the vast majority of neurons (approximately 90%, n > 250), currents were exclusively of the high-voltage-activated (HVA) type. HVA currents activated near -40 mV and reached their maximum amplitude near 0 mV. Quasi-steady-state inactivation curves in many neurons were well fitted only with a sum of Boltzmann functions, suggesting that the HVA currents were heterogeneous… CONTINUE READING
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