Cellular and molecular biological analyses of nifurtimox resistance in Trypanosoma cruzi.

@article{Nozaki1996CellularAM,
  title={Cellular and molecular biological analyses of nifurtimox resistance in Trypanosoma cruzi.},
  author={Tomoyoshi Nozaki and Juan C. Engel and James A. Dvorak},
  journal={The American journal of tropical medicine and hygiene},
  year={1996},
  volume={55 1},
  pages={111-7}
}
We induced nifurtimox resistance in both epimastigotes and tissue culture-derived trypomastigotes of several Trypanosoma cruzi strains. The magnitude of nifurtimox resistance was strain-dependent. A variety of karyotype changes occurred in the nifurtimox-resistant (NR) strains. Chromosome-specific DNA probes identified karyotype changes common to the NR strains that were moderately resistant to nifurtimox but not the NR strains that were highly resistant to nifurtimox. A marked increase in… CONTINUE READING