Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.

  title={Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.},
  author={Bal{\'a}zs Gereben and Ann Marie Zavacki and Scott A Ribich and Brian W. Kim and Stephen A. Huang and Warner S. Simonides and Anik{\'o} Ze{\"o}ld and Antonio Carlos Mugayar Bianco},
  journal={Endocrine reviews},
  volume={29 7},
The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore are critical for the biological effects mediated by thyroid hormone. Over the years, research has focused on their role in preserving serum levels of the biologically active molecule T(3) during iodine deficiency. More recently, a fascinating new role of these enzymes has been unveiled. The activating deiodinase (D2) and the inactivating deiodinase (D3) can locally increase or decrease thyroid hormone… CONTINUE READING
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