Cellular and molecular basis of pulmonary arterial hypertension.

  title={Cellular and molecular basis of pulmonary arterial hypertension.},
  author={Nicholas W Morrell and Serge Adnot and Stephen L Archer and Jocelyn Dupuis and Peter Lloyd Jones and Margaret R. Maclean and Ivan F. McMurtry and Kurt R Stenmark and Patricia A. Thistlethwaite and Norbert Weissmann and Jason X-J Yuan and Edward Kenneth Weir},
  journal={Journal of the American College of Cardiology},
  volume={54 1 Suppl},
Pulmonary arterial hypertension (PAH) is caused by functional and structural changes in the pulmonary vasculature, leading to increased pulmonary vascular resistance. The process of pulmonary vascular remodeling is accompanied by endothelial dysfunction, activation of fibroblasts and smooth muscle cells, crosstalk between cells within the vascular wall, and recruitment of circulating progenitor cells. Recent findings have reestablished the role of chronic vasoconstriction in the remodeling… CONTINUE READING
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