Cellular and molecular basis of liver development.

  title={Cellular and molecular basis of liver development.},
  author={Donghun Shin and Satdarshan Pal Singh Monga},
  journal={Comprehensive Physiology},
  volume={3 2},
Liver is a prime organ responsible for synthesis, metabolism, and detoxification. The organ is endodermal in origin and its development is regulated by temporal, complex, and finely balanced cellular and molecular interactions that dictate its origin, growth, and maturation. We discuss the relevance of endoderm patterning, which truly is the first step toward mapping of domains that will give rise to specific organs. Once foregut patterning is completed, certain cells within the foregut… CONTINUE READING