Cellular and molecular basis for the regulation of inflammation by TGF-beta.

  title={Cellular and molecular basis for the regulation of inflammation by TGF-beta.},
  author={Akihiko Yoshimura and Yu Wakabayashi and Tomoaki Mori},
  journal={Journal of biochemistry},
  volume={147 6},
Transforming growth factor-beta (TGF-beta) has been shown to play an essential role in the suppression of inflammation, yet recent studies have revealed the positive roles of TGF-beta in inflammatory responses. For example, TGF-beta induces Foxp3-positive regulatory T cells (iTregs) in the presence of interleukin-2 (IL-2), while in the presence of IL-6, it induces pathogenic IL-17 producing Th17 cells. TGF-beta inhibits the proliferation of immune cells as well as cytokine production via Foxp3… CONTINUE READING


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Smad2 and Smad3 are redundantly essential for the TGF-bmediated regulation of Treg plasticity and Th1 cell development

  • T. Takimoto, Y. Wakabayashi, +11 authors A. Yoshimura
  • J. Immunol.,
  • 2010
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