Cellular and molecular basis for the regulation of inflammation by TGF-beta.

@article{Yoshimura2010CellularAM,
  title={Cellular and molecular basis for the regulation of inflammation by TGF-beta.},
  author={Akihiko Yoshimura and Yu Wakabayashi and Tomoaki Mori},
  journal={Journal of biochemistry},
  year={2010},
  volume={147 6},
  pages={781-92}
}
Transforming growth factor-beta (TGF-beta) has been shown to play an essential role in the suppression of inflammation, yet recent studies have revealed the positive roles of TGF-beta in inflammatory responses. For example, TGF-beta induces Foxp3-positive regulatory T cells (iTregs) in the presence of interleukin-2 (IL-2), while in the presence of IL-6, it induces pathogenic IL-17 producing Th17 cells. TGF-beta inhibits the proliferation of immune cells as well as cytokine production via Foxp3… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 118 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 125 references

Smad2 and Smad3 are redundantly essential for the TGF-bmediated regulation of Treg plasticity and Th1 cell development

  • T. Takimoto, Y. Wakabayashi, +11 authors A. Yoshimura
  • J. Immunol.,
  • 2010
Highly Influential
20 Excerpts

Similar Papers

Loading similar papers…