Cellular and molecular bases of B-cell clonal expansions.

  title={Cellular and molecular bases of B-cell clonal expansions.},
  author={Riccardo Dolcetti and Mauro Boiocchi},
  journal={Clinical and experimental rheumatology},
  volume={14 Suppl 14},
The concept that lymphomagenesis is a multistep process is now widely accepted. Various factors are involved in the development and malignant progression of B-cell lymphoproliferative disorders. The most frequently recognized alterations in these disorders are chromosomal translocations which lead to the activation of proto-oncogenes (c-myc) or genes encoding for proteins involved in the control of the cell cycle (cyclin D1), differentiation (bcl-6) and apoptosis (bcl-2). In addition, genetic… CONTINUE READING


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