Cellular and molecular aspects of drugs of the future: oxaliplatin

  title={Cellular and molecular aspects of drugs of the future: oxaliplatin},
  author={Angela Maria Di Francesco and Antonietta Ruggiero and Riccardo Riccardi},
  journal={Cellular and Molecular Life Sciences CMLS},
Oxaliplatin (Eloxatine) is a third-generation platinum compound which has shown a wide antitumour effect both in vitro and in vivo, a better safety profile than cisplatin and a lack of cross-resistance with cisplatin and carboplatin. In this scenario, oxaliplatin may represent an innovative and challenging drug extending the antitumour activity in diseases such as gastrointestinal cancer that are not usually sensitive to these coordination complexes. Oxaliplatin has a non-hydrolysable… CONTINUE READING


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