Cellular and molecular abnormalities in severe congenital neutropenia predisposing to leukemia.

@article{Aprikyan2003CellularAM,
  title={Cellular and molecular abnormalities in severe congenital neutropenia predisposing to leukemia.},
  author={Andrew A. G. Aprikyan and Tatyana Kutyavin and Steven J. Stein and Pavel Aprikian and Elin Rodger and W Conrad Liles and Laurence Boxer and David C Dale},
  journal={Experimental hematology},
  year={2003},
  volume={31 5},
  pages={372-81}
}
Severe congenital neutropenia (SCN) is a rare hematological disease characterized by a selective decrease in the level of circulating neutrophils in peripheral blood, maturation arrest at the promyelocyte stage of differentiation in the bone marrow, recurrent severe infections, and evolution to acute myelogenous leukemia (AML). Cellular and molecular studies of 12 SCN patients, including 5 patients that evolved to develop AML, revealed impaired proliferative characteristics and accelerated… CONTINUE READING

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