Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death.

@article{Tirosh2000CellularAM,
  title={Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death.},
  author={Oren Tirosh and Chandan K. Sen and Sophie le Roy and Lester Packer},
  journal={Neuroscience},
  year={2000},
  volume={97 3},
  pages={531-41}
}
Elevated levels of extracellular glutamate are neurotoxic. The cytotoxic property of extracellular glutamate is known to mediate two primary mechanisms, excitotoxicity and excitotoxicity-independent processes. The excitotoxicity-independent pathway was investigated in the current study in a mouse hippocampal-derived HT4 cell line. Exposure of HT4 cells to glutamate for 12h induced loss of cell viability preceded by rapid loss of intracellular reduced glutathione followed by accumulation of… CONTINUE READING