Cellular and membrane properties of alpha and beta thalassemic erythrocytes are different: implication for differences in clinical manifestations.

@article{Schrier1989CellularAM,
  title={Cellular and membrane properties of alpha and beta thalassemic erythrocytes are different: implication for differences in clinical manifestations.},
  author={Stanley L. Schrier and E Rachmilewitz and Narla Mohandas},
  journal={Blood},
  year={1989},
  volume={74 6},
  pages={2194-202}
}
To define how excess unpaired alpha- and beta-globin chains in severe beta-thalassemia and severe alpha-thalassemia interacting with the membrane might alter cellular and membrane properties, we performed a series of biophysical and biochemical analyses on erythrocytes obtained from affected patients. Detailed analysis of cellular and membrane deformability characteristics showed that both forms of thalassemic erythrocytes have excess surface area in relation to cell volume and increased… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 34 references

Isolated ( 3globin chains reproduce the defective binding of spectrin to athalassemic inside - out membrane vesicles

  • 0 Shalev, E Shinar, SE Lux
  • Blood
  • 1988

Isolation and characterization of the hemichromestabilized membrane protein aggregates from sickled erythrocytes

  • R Kannan, R Laborka, PS Low
  • J Biol Chem
  • 1988

Erythro - cyte membrane skeletal abnormalities in severe fithalassemia

  • E Shinar, 0 Shalev, EA Rachmilewitz, Schrier Si
  • Blood
  • 1987

Majerus P (eds): The Molecular Bases of Blood Diseases

  • A Nienhuis, P. Leder
  • 1987

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