Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil.

@article{Aiba2005CellularAI,
  title={Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil.},
  author={Takeshi Aiba and Wataru Shimizu and Masashi Inagaki and Takashi Noda and Shunichiro Miyoshi and W. G. Ding and Dimitar P. Zankov and Futoshi Toyoda and Hiroshi Matsuura and Minoru Horie and Kenji Sunagawa},
  journal={Journal of the American College of Cardiology},
  year={2005},
  volume={45 2},
  pages={300-7}
}
OBJECTIVES We examined the cellular and ionic mechanism for QT prolongation and subsequent Torsade de Pointes (TdP) and the effect of verapamil under conditions mimicking KCNQ1 (I(Ks) gene) defect linked to acquired long QT syndrome (LQTS). BACKGROUND Agents with an I(Kr)-blocking effect often induce marked QT prolongation in patients with acquired LQTS. Previous reports demonstrated a relationship between subclinical mutations in cardiac K+ channel genes and a risk of drug-induced TdP… CONTINUE READING
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