Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype.

@article{Park2010CellularAG,
  title={Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype.},
  author={So Yeon Park and Mithat G{\"o}nen and Hee Jung Kim and Franziska Michor and Kornelia Polyak},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 2},
  pages={
          636-44
        }
}
Intratumor genetic heterogeneity is a key mechanism underlying tumor progression and therapeutic resistance. The prevailing model for explaining intratumor diversity, the clonal evolution model, has recently been challenged by proponents of the cancer stem cell hypothesis. To investigate this issue, we performed combined analyses of markers associated with cellular differentiation states and genotypic alterations in human breast carcinomas and evaluated diversity with ecological and… CONTINUE READING

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