Cellular and genetic basis for suppression of cytotoxic T cell generation by haloaromatic hydrocarbons.

Abstract

Generation of allospecific cytotoxic T cells in C57Bl/6 mice is significantly impaired following exposure to TCDD at doses as low as 4 ng/kg. T helper activity, as assessed by the ability to produce Interleukin 2, and frequency of CTL precursors appear unaffected in treated animals and thus the TCDD-induced suppressor cells we have described are primarily… (More)

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Cite this paper

@article{Clark1983CellularAG, title={Cellular and genetic basis for suppression of cytotoxic T cell generation by haloaromatic hydrocarbons.}, author={D. A. Clark and Gary Sweeney and S. Safe and E. William Hancock and Duncan Kilburn and Jack Gauldie}, journal={Immunopharmacology}, year={1983}, volume={6 2}, pages={143-53} }