Cellular and developmental properties of fetal hematopoietic stem cells.

  title={Cellular and developmental properties of fetal hematopoietic stem cells.},
  author={Craig T. Jordan and J P Mckearn and Ihor Lemischka},
  volume={61 6},
We have characterized the fetal totipotent hematopoietic stem cell using a novel strategy that integrates physical analysis of cell properties and genetic analysis of in vivo developmental behavior. This approach allows the simultaneous isolation and in vivo characterization of any stem cell population. Using this procedure we demonstrate that a cell surface marker, recognized by monoclonal antibody AA4.1, defines 0.5%-1.0% of fetal liver tissue that contains the entire hierarchy of primitive… CONTINUE READING

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