Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology.

  title={Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology.},
  author={Candy Chuah and Malcolm Kenneth Jones and Melissa L. Burke and Donald P McManus and Geoffrey N. Gobert},
  journal={Trends in parasitology},
  volume={30 3},
In hepatic schistosomiasis, pathology arises when schistosome eggs become lodged in the host liver, evoking an interleukin 4 (IL-4)- and IL-13-mediated dominant CD4(+) Th2 immune response. This response leads to the development of granulomas and fibrosis, with eosinophils, neutrophils, macrophages, hepatic stellate cells, and lymphocytes all identified as major cellular contributors to these events. This review outlines the cellular and molecular mechanisms of hepatic schistosomiasis, with an… CONTINUE READING
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