Cellular and Pharmacogenetics Foundation of Synergistic Interaction of Pemetrexed and Gemcitabine in Human Non–Small-Cell Lung Cancer Cells

@article{Giovannetti2005CellularAP,
  title={Cellular and Pharmacogenetics Foundation of Synergistic Interaction of Pemetrexed and Gemcitabine in Human Non–Small-Cell Lung Cancer Cells},
  author={Elisa Giovannetti and Valentina Mey and Sara Nannizzi and Giuseppe Pasqualetti and Luca Marini and Mario del Tacca and Romano Danesi},
  journal={Molecular Pharmacology},
  year={2005},
  volume={68},
  pages={110 - 118}
}
Gemcitabine and pemetrexed are effective agents in the treatment of non–small-cell lung cancer (NSCLC), and the present study investigates cellular and genetic aspects of their interaction against A549, Calu-1, and Calu-6 cells. Cells were treated with pemetrexed and gemcitabine, and their interaction was assessed using the combination index. The role of drug metabolism in gemcitabine cytotoxicity was examined with inhibitors of deoxycytidine kinase (dCK), 5′-nucleotidase, and cytidine… 

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