Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases

  title={Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases},
  author={Mark P. Mattson and Ward A. Pedersen and W. Duan and Carsten Culmsee and Simonetta Camandola},
  journal={Annals of the New York Academy of Sciences},
ABSTRACT: Synaptic degeneration and death of nerve cells are defining features of Alzheimer's disease (AD) and Parkinson's disease (PD), the two most prevalent age‐related neurodegenerative disorders. In AD, neurons in the hippocampus and basal forebrain (brain regions that subserve learning and memory functions) are selectively vulnerable. In PD dopamine‐producing neurons in the substantia nigra‐striatum (brain regions that control body movements) selectively degenerate. Studies of postmortem… 

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  • Biology
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  • 2006
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