Cellular and Molecular Effect of MEHP Involving LXRα in Human Fetal Testis and Ovary

@inproceedings{Muczynski2012CellularAM,
  title={Cellular and Molecular Effect of MEHP Involving LXRα in Human Fetal Testis and Ovary},
  author={Vincent Muczynski and Charlotte L{\'e}cureuil and S{\'e}bastien Messiaen and Marie-Justine Guerquin and Thierry N’Tumba-Byn and Delphine Moison and Wassim Hodroj and Hinde Benjelloun and Jan Baijer and Gabriel Livera and Ren{\'e} Frydman and Alexandra Benachi and Ren{\'e} Habert and Virginie Rouiller-Fabre},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Phthalates have been shown to have reprotoxic effects in rodents and human during fetal life. Previous studies indicate that some members of the nuclear receptor (NR) superfamilly potentially mediate phthalate effects. This study aimed to assess if expression of these nuclear receptors are modulated in the response to MEHP exposure on the human fetal gonads in vitro. METHODOLOGY/PRINCIPAL FINDINGS Testes and ovaries from 7 to 12 gestational weeks human fetuses were exposed to 10(-4… CONTINUE READING
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