Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1

@inproceedings{Wu2013CellularAB,
  title={Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1},
  author={Li Wu},
  booktitle={ISRN biochemistry},
  year={2013}
}
  • Li Wu
  • Published 2013 in ISRN biochemistry
Replication of HIV-1 and other retroviruses is dependent on numerous host proteins in the cells. Some of the host proteins, however, function as restriction factors to block retroviral infection of target cells. The host protein SAMHD1 has been identified as the first mammalian deoxynucleoside triphosphate triphosphohydrolase (dNTPase), which blocks the… CONTINUE READING