Cellular adhesion pathways and metastatic potential of human melanoma.

  title={Cellular adhesion pathways and metastatic potential of human melanoma.},
  author={Eric C. McGary and Dina Chelouche Lev and Menashe M Bar-Eli},
  journal={Cancer biology & therapy},
  volume={1 5},
Cellular adhesion molecules of the cadherin, integrin, and immunoglobulin superfamilies are important to both growth and metastasis of many cancers, including malignant melanoma. Malignant melanoma is an excellent model for studying these molecules, due in part to a sequential series of five defineable stages. As the malignant phenotype of melanoma cells changes from the noninvasive radial growth phase to the vertical growth phase, which has high metastatic potential, so does the repertoire of… CONTINUE READING