Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment.

Abstract

The effect of intralysosomal proteolysis of near-infrared fluorescent (NIRF) self-quenched macromolecular probe (PGC-Cy5.5) has been previously reported and used for tumor imaging. Here we demonstrate that proteolysis can be detected noninvasively in vivo at the cellular level. A codetection of GFP fluorescence (using two-photon excitation) and NIRF was… (More)

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Cite this paper

@article{Bogdanov2002CellularAO, title={Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment.}, author={Alexei A. Bogdanov and Charles Lin and Maria A Simonova and Lars Matuszewski and Ralph Weissleder}, journal={Neoplasia}, year={2002}, volume={4 3}, pages={228-36} }