Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway.

@article{Morrison2001CellularAO,
  title={Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway.},
  author={Charlotte J. Morrison and Georgina S. Butler and Heather F Bigg and Clive R. Roberts and Paul D. Soloway and Christopher M. Overall},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 50},
  pages={47402-10}
}
The role of membrane-type (MT) 2-matrix metalloproteinase (MMP) in the cellular activation of MMP-2 and the tissue inhibitor of matrix metalloproteinase (TIMP) requirements for this process have not been clearly established. To address these issues a TIMP-2-free cell line derived from a Timp2-/- mouse was transfected for stable cell surface expression of hMT2-MMP. Untransfected cells did not activate endogenous or exogenous TIMP-2-free MMP-2 unless both TIMP-2 and concanavalin A (ConA) were… CONTINUE READING

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Activation of MMP-2 by MT2-MMP

C. J. Morrison, W. R. McMaster, J. M. Piret
Biotechnol. Bioeng • 1997

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