Cellular activation by thromboxane A2 and other eicosanoids.

  title={Cellular activation by thromboxane A2 and other eicosanoids.},
  author={Marie A. Reilly and Garret A. FitzGerald},
  journal={European heart journal},
  volume={14 Suppl K},
Thromboxane A2 (TXA2), the major cyclooxygenase (COX) product of arachidonic acid (AA), activates platelets and is a potent vasoconstrictor. The functional importance of this eicosanoid has been demonstrated in syndromes of acute coronary ischaemia. The cellular response to this agonist is tightly regulated. The liberation of AA from membrane phospholipids is conventionally thought to be the rate limiting step in TXA2 biosynthesis. However, the discovery of a second, highly regulated COX gene… CONTINUE READING


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