Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1.

@article{Vaughan2003CellularAO,
  title={Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1.},
  author={Christopher W Vaughan and Elena E Bagley and Geoffrey M Drew and A. Schuller and John E. Pintar and Stephen P. Hack and Macdonald J Christie},
  journal={British journal of pharmacology},
  year={2003},
  volume={139 2},
  pages={362-7}
}
1 Patch clamp recordings were made from periaqueductal grey (PAG) neurons in vitro to investigate the cellular actions of opioids in wild-type C57B16/J mice and mutant mice lacking the first exon of the micro -opioid (MOP) receptor. 2 In wild-type mice, the kappa-(KOP) agonist U-69593 (300 nM) and the mixed micro /delta-opioid agonist met-enkephalin (10 micro M), but not the delta-(DOP) agonist deltorphin (300 nM), reduced the amplitude of evoked GABA(A)-mediated inhibitory postsynaptic… CONTINUE READING

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