Cellular action of thyroid hormone on the heart.

  title={Cellular action of thyroid hormone on the heart.},
  author={Wolfgang H. Dillmann},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={12 6},
Changes in thyroid status markedly influence cardiac contractile and electrical activity. The predominant route by which triiodothyronine (T3) affects cardiac action is by exerting a direct effect in cardiac myocytes through binding to thyroid hormone nuclear receptor isoforms. In addition, T3 modifies cardiac action by alterations in the vascular system and decreases afterload of the left ventricle by subtle modification related to the sympathetic system. The importance of T3 nuclear receptor… CONTINUE READING
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