Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.

@article{Sun2010CellularAO,
  title={Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.},
  author={Tingting Sun and Xiaomei Yang and Wei Wang and Xiaojuan Zhang and Quanbin Xu and Songcheng Zhu and Robert D. Kuchta and Guanjun Chen and Xuedong Liu},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 49},
  pages={38730-9}
}
Mps1 is a protein kinase that regulates normal mitotic progression and the spindle checkpoint in response to spindle damage. The levels of Mps1 are relatively low in cells during interphase but elevated in mitosis or upon activation of the spindle checkpoint, although the dynamic range of Mps1 expression and the Mps1 catalytic mechanism have not been carefully characterized. Our recent structural studies of the Mps1 kinase domain revealed that the carboxyl-terminal tail region of Mps1 is… CONTINUE READING