Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

@article{Antony2005CellularTI,
  title={Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison},
  author={S. Antony and G. Kohlhagen and K. Agama and M. Jayaraman and S. Cao and F. Durrani and Y. Rustum and M. Cushman and Y. Pommier},
  journal={Molecular Pharmacology},
  year={2005},
  volume={67},
  pages={523 - 530}
}
  • S. Antony, G. Kohlhagen, +6 authors Y. Pommier
  • Published 2005
  • Biology, Medicine
  • Molecular Pharmacology
  • To overcome camptothecin's (CPT) lactone instability, reversibility of the drug-target interaction, and drug resistance, attempts to synthesize compounds that are CPT-like in their specificity and potency yet display a unique profile have been underway. In this pursuit, we have identified one of the idenoisoquinoline derivatives, MJ-III-65 (NSC 706744; 6-[3-(2-hydroxyethyl)amino-1-propyl]-5,6-dihydro-2,3-dimethoxy-8,9-methylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline) with both… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    Background: The new drug LMP744 damages DNA. This causes cell death. Researchers want to see if it can treat certain kinds of cancer. They want to understand how the drug works… Expand
    ConditionsLymphoma, Solid Tumors
    InterventionDrug
    The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
    114
    Bisindenoisoquinoline NSC 727357, a DNA intercalator and topoisomerase inhibitor with antitumor activity
    6

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 38 REFERENCES
    Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.
    96
    2"-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons.
    18