Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

@article{Antony2005CellularTI,
  title={Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison},
  author={Smitha Antony and Glenda Kohlhagen and Keli Agama and Muthusamy Jayaraman and Shousong Cao and Farukh A. Durrani and Youcef M. Rustum and Mark Cushman and Yves Pommier},
  journal={Molecular Pharmacology},
  year={2005},
  volume={67},
  pages={523 - 530}
}
To overcome camptothecin's (CPT) lactone instability, reversibility of the drug-target interaction, and drug resistance, attempts to synthesize compounds that are CPT-like in their specificity and potency yet display a unique profile have been underway. In this pursuit, we have identified one of the idenoisoquinoline derivatives, MJ-III-65 (NSC 706744; 6-[3-(2-hydroxyethyl)amino-1-propyl]-5,6-dihydro-2,3-dimethoxy-8,9-methylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline) with both… Expand
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