Cellular Strategies for Regulating Functional and Nonfunctional Protein Aggregation

@inproceedings{Gsponer2012CellularSF,
  title={Cellular Strategies for Regulating Functional and Nonfunctional Protein Aggregation},
  author={J{\"o}rg Gsponer and M. Madan Babu},
  booktitle={Cell reports},
  year={2012}
}
Growing evidence suggests that aggregation-prone proteins are both harmful and functional for a cell. How do cellular systems balance the detrimental and beneficial effect of protein aggregation? We reveal that aggregation-prone proteins are subject to differential transcriptional, translational, and degradation control compared to nonaggregation-prone proteins, which leads to their decreased synthesis, low abundance, and high turnover. Genetic modulators that enhance the aggregation phenotype… CONTINUE READING