Corpus ID: 236428810

Cellular Sensing Governs the Stability of Chemotactic Fronts

@inproceedings{Alert2021CellularSG,
  title={Cellular Sensing Governs the Stability of Chemotactic Fronts},
  author={Ricard Alert and Sujit S. Datta},
  year={2021}
}
In contexts ranging from embryonic development to bacterial ecology, cell populations migrate chemotactically along self-generated chemical gradients, often forming a propagating front. Here, we theoretically show that the stability of such chemotactic fronts to morphological perturbations is determined by limitations in the ability of individual cells to sense and thereby respond to the chemical gradient. Specifically, cells at bulging parts of a front are exposed to a smaller gradient, which… Expand
1 Citations

Figures and Tables from this paper

Active transport in complex environments
TLDR
This research presents a new generation of probabilistic models that allow for the estimation of the carrier and removal of disease-causing “ghost cells” in the response of the immune system. Expand

References

SHOWING 1-10 OF 94 REFERENCES
The principles of directed cell migration.
TLDR
Use of these four pillars has allowed us to compare some of the similarities between different types of directed migration, but also to highlight the remarkable diversity in the mechanisms that cells use to respond to different cues provided by their environment. Expand
Chemotaxis as a navigation strategy to boost range expansion
TLDR
This work identifies an alternative role of chemotaxis by systematically examining the spatiotemporal dynamics of Escherichia coli in soft agar and concludes that this process of navigated range expansion spreads faster and yields larger population gains than unguided expansion following the canonical Fisher–Kolmogorov dynamics. Expand
Synthetic Chemotaxis and Collective Behavior in Active Matter.
TLDR
Besides the classical case where chemical interactions are attractive, this Account discusses, as its main focus, repulsive chemical interactions, which can create a new and less known avenue to pattern formation in active systems leading to a variety of pattern, including clusters which are surrounded by shells of chemicals, traveling waves and more complex continuously reshaping patterns. Expand
Chemotactic Migration of Bacteria in Porous Media
TLDR
How confinement in a porous medium fundamentally alters the chemotactic migration of Escherichia coli is demonstrated and provides a framework to predict and control the migration of bacteria, and active matter in general, in heterogeneous porous environments. Expand
Mechanical guidance of cell migration: lessons from chemotaxis.
TLDR
It is shown that both chemotaxis and mechanotaxis involve an exquisite interplay between physical and chemical mechanisms to sense gradients, establish polarization, and drive directed migration. Expand
Collective Cell Motility Promotes Chemotactic Prowess and Resistance to Chemorepulsion
TLDR
It is shown that, upon exposure to CCL19 or CXCL12 gradients, malignant B and T lymphocytes assemble into clusters that migrate directionally and display a wider chemotactic sensitivity than individual cells. Expand
Cell–cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis
TLDR
It is found that multicellular sensing enables detection of and response to shallow epidermal growth factor (EGF) gradients that are undetectable by single cells, and this provides a framework for understanding the advantages and limitations of sensory information processing by relays of chemically coupled cells. Expand
Physical mechanisms for chemotactic pattern formation by bacteria.
TLDR
A theory for chemotactic pattern formation by the bacteria Escherichia coli in the presence of excreted attractant is formulates and several scaling laws are proposed and are demonstrated to be consistent with experimental data. Expand
Cooperative self-organization of microorganisms
TLDR
This work presents a wealth of beautiful patterns formed during colony development of various microorganisms and for different environmental conditions and demonstrates how communication leads to self-organization via cooperative behaviour of the cells. Expand
Complex patterns formed by motile cells of Escherichia coli
TLDR
Conditions under which cells aggregate in response to gradients of attractant which they excrete themselves are described, which might serve as a mechanism for collective defence. Expand
...
1
2
3
4
5
...