Cellular Senescence and Stem Cell Niche

  title={Cellular Senescence and Stem Cell Niche},
  author={Arthur M. Krause and Michael J. Conboy and Irina M. Conboy},
Mankind is reaching older ages and ironically faces previously unknown health issues that are associated with living past the 5th decade. Aging is not only visible phenotypically; but it also results in decline of tissue regenerative capacity and abandonment of organ maintenance and repair by dedicated stem cells. Consequentially, damage and attrition accumulate leading to broad and progressive organ failure (known as mammalian aging). This chapter focuses on the link between the age-imposed… CONTINUE READING

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