Cellular Senescence Controlled by p53 is a Barrier to Environmental

  title={Cellular Senescence Controlled by p53 is a Barrier to Environmental},
  author={Carcinogenesisdel Mar Vergel and Sandra Mu{\~n}oz-Galv{\'a}n and Daniel Otero-Albiol and Amancio Carnero},
Cancer development in humans and animals may be caused by environmental factors. It has been estimated that approximately 80% of human tumors are generated by exposure to environmental carcinogens. The carcinogens may initiate or induce progression of tumors in several ways. Cellular senescence is a natural barrier used by cells to respond to stress. The molecular analysis of immortal clones shows alterations, either structural or epigenetic, in the genes involved in cellular senescence. It is… Expand

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