Cellular Retinoic Acid Bioavailability Determines Epithelial Integrity: Role of Retinoic Acid Receptor α Agonists in Colitis

@article{Osanai2007CellularRA,
  title={Cellular Retinoic Acid Bioavailability Determines Epithelial Integrity: Role of Retinoic Acid Receptor $\alpha$ Agonists in Colitis},
  author={Makoto Osanai and Nami Nishikiori and Masaki Murata and Hideki Chiba and Takashi Kojima and Norimasa Sawada},
  journal={Molecular Pharmacology},
  year={2007},
  volume={71},
  pages={250 - 258}
}
The epithelial barrier is determined primarily by intercellular tight junctions (TJs). We have demonstrated previously that all-trans retinoic acid (atRA) plays an important role in forming functional TJs through a specific retinoic acid receptor (RAR)/retinoid X receptor heterodimer in epithelial cells. However, the physiological relevance of retinoic acids (RAs) in maintaining the epithelial integrity remains to be examined. Here, we show that several types of RA, including atRA, promote the… 

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