Cellular Resistance to Infection

@article{Mackaness1962CellularRT,
  title={Cellular Resistance to Infection},
  author={G. B. Mackaness},
  journal={The Journal of Experimental Medicine},
  year={1962},
  volume={116},
  pages={381 - 406}
}
The mouse was found to be natively susceptible to Listeria monocytogenes. Its susceptibility was attributed to the capacity of the organism to survive and multiplying in host macrophages. During the first 3 days of a primary infection the bacterial populations of spleen and liver were found to increase at a constant rate. On the 4th day of infection the host became hypersensitive to Listeria antigens and at the same time bacterial growth ceased. A rapid inactivation of the organism ensued… CONTINUE READING

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