Cellular Reprogramming Employing Recombinant Sox2 Protein

  title={Cellular Reprogramming Employing Recombinant Sox2 Protein},
  author={Marc Christian Thier and Bernhard M{\"u}nst and Stephanie Mielke and Frank Edenhofer},
  booktitle={Stem cells international},
Induced pluripotent stem (iPS) cells represent an attractive option for the derivation of patient-specific pluripotent cells for cell replacement therapies as well as disease modeling. To become clinically meaningful, safe iPS cells need to be generated exhibiting no permanent genetic modifications that are caused by viral integrations of the reprogramming transgenes. Recently, various experimental strategies have been applied to accomplish transgene-free derivation of iPS cells, including the… CONTINUE READING


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