Cellular Reactions of Osteoblasts to Micron- and Submicron-Scale Porous Structures of Titanium Surfaces

@article{Zhu2004CellularRO,
  title={Cellular Reactions of Osteoblasts to Micron- and Submicron-Scale Porous Structures of Titanium Surfaces},
  author={Xiaolong Zhu and Jun Chen and Lutz Scheideler and Thomas Altebaeumer and Juergen Geis-Gerstorfer and Dieter P Kern},
  journal={Cells Tissues Organs},
  year={2004},
  volume={178},
  pages={13 - 22}
}
Osteoblast reactions to topographic structures of titanium play a key role in host tissue responses and the final osseointegration. Since it is difficult to fabricate micro- and nano-scale structures on titanium surfaces, little is known about the mechanism whereby the topography of titanium surfaces exerts its effects on cell behavior at the cellular level. In the present study, the titanium surface was structured in micron- and submicron-scale ranges by anodic oxidation in either 0.2 M H3PO4… 
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References

SHOWING 1-10 OF 53 REFERENCES
Effect of grooved titanium substratum on human osteoblastic cell growth.
TLDR
It appears that cultured human osteoblasts prefer surfaces with relatively high micro-roughness amplitude and with a low level of repeatability, compared with previous research which found that surface roughness must be taken into account.
Behavior of SaOS-2 Cells Cultured on Different Titanium Surfaces
TLDR
The results indicate that titanium surface topography affects proliferation and differentiation of osteoblast-like SaOS-2 cells, suggesting that surface properties might be important for bone response around dental implants in vivo.
The influence of pore geometry in cp Ti-implants--a cell culture investigation.
TLDR
The analysis of the cell culture results demonstrated that 25 microm and 200 microm porous geometries showed similar or even better results than the negative control of polystyrene; there was no sign of toxic effects.
The role of implant surface characteristics in the healing of bone.
TLDR
This review will focus on how surface characteristics, such as composition and roughness, affect cellular response to an implant material.
In vivo histological response to anodized and anodized/hydrothermally treated titanium implants.
TLDR
It was concluded that the surface anodized implants resulted in a high interfacial strength at an early implantation period as compared to the nontreated titanium implants.
Characterizations of titanium implant surfaces. III.
TLDR
Surface analysis indicated that with the exception of oxide thickness, there were no significant differences in surface characteristics between the two implant materials, which continue to indicate that cpTi and Ti alloy are suitable, biologically compatible materials for fabrication of dental implants.
Mechanisms Involved in Osteoblast Response to Implant Surface Morphology
TLDR
Osteoblasts respond to surface topography with altered morphology, proliferation, and differentiation, and cell responses to hormones, growth factors, and cytokines are altered as well, as is autocrine production of these factors.
Nanofabrication in cellular engineering
Biological cells are strongly influenced by the topography of the surface on which they live, both in cell culture and in an animal. They are guided along micron sized grooves and change their shape
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