Cellular Prion Protein: From Physiology to Pathology

  title={Cellular Prion Protein: From Physiology to Pathology},
  author={Sei-ichi Yusa and Jos{\'e} B. Oliveira-Martins and Yoshiko Sugita-Konishi and Yutaka Kikuchi},
The human cellular prion protein (PrP(C)) is a glycosylphosphatidylinositol (GPI) anchored membrane glycoprotein with two N-glycosylation sites at residues 181 and 197. This protein migrates in several bands by Western blot analysis (WB). Interestingly, PNGase F treatment of human brain homogenates prior to the WB, which is known to remove the N… CONTINUE READING