Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder

  title={Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder},
  author={Robert J. Schloesser and Jian Huang and Peter S Klein and Husseini K. Manji},
Bipolar disorder (BPD) is characterized by recurrent episodes of disturbed affect including mania and depression as well as changes in psychovegetative function, cognitive performance, and general health. A growing body of data suggests that BPD arises from abnormalities in synaptic and neuronal plasticity cascades, leading to aberrant information processing in critical synapses and circuits. Thus, these illnesses can best be conceptualized as genetically influenced disorders of synapses and… 

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