Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals

@article{McKenzie2005CellularNR,
  title={Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals},
  author={Grahame J. McKenzie and G. A. Abou Ward and Yvette Stallwood and Emmanuel Briend and Sofia Papadia and Andrew Lennard and Martin Turner and Brian Champion and Giles E Hardingham},
  journal={BMC Cell Biology},
  year={2005},
  volume={7},
  pages={10 - 10}
}
Notch plays a wide-ranging role in controlling cell fate, differentiation and development. The PI3K-Akt pathway is a similarly conserved signalling pathway which regulates processes such as differentiation, proliferation and survival. Mice with disrupted Notch and PI3K signalling show phenotypic similarities during haematopoietic cell development, suggesting functional interaction between these pathways. We show that cellular responsiveness to Notch signals depends on the activity of the PI3K… CONTINUE READING