In recent years, grid-shaped cellular models have gained popularity to understand physical systems. Complex cell spaces can require large amounts of compute time, mainly due to its synchronous nature; the use of a discrete time base also constrains the precision of the model. The Cell-DEVS formalism was defined in order to deal with these issues. We give a brief introduction to the main characteristics of Cell-DEVS, and show how to use the method to model complex cell spaces. We present different examples of application, and show how to integrate cellular models with external data collection and visualization.