Cellular Mechanisms of Social Attachment

@article{Young2001CellularMO,
  title={Cellular Mechanisms of Social Attachment},
  author={Larry J. Young and Miranda M. Lim and Brenden Gingrich and Thomas R. Insel},
  journal={Hormones and Behavior},
  year={2001},
  volume={40},
  pages={133-138}
}
Pharmacological studies in prairie voles have suggested that the neuropeptides oxytocin and vasopressin play important roles in behaviors associated with monogamy, including affiliation, paternal care, and pair bonding. Our laboratory has investigated the cellular and neuroendocrine mechanisms by which these peptides influence affiliative behavior and social attachment in prairie voles. Monogamous prairie voles have a higher density of oxytocin receptors in the nucleus accumbens than do… 
Distributions of oxytocin and vasopressin 1a receptors in the Taiwan vole and their role in social monogamy.
TLDR
The neuroanatomical distribution of OTR and V1aR binding sites in naturally occurring populations of Taiwan voles, which purportedly display social monogamy, is characterized to lay a foundation for future investigations into the role of these neuropeptides in Taiwan vole social behavior.
Characterization of the oxytocin system regulating affiliative behavior in female prairie voles
TLDR
It is shown for the first time that extracellular concentrations of oxytocin are increased in the nucleus accumbens of female prairie vole during unrestricted interactions with a male, and it is shown that the distribution of Oxytocin-immunoreactive fibers in the cluster is conserved in voles, mice and rats, despite remarkable species differences in oxytocIn receptor binding in the region.
Ventral tegmental area involvement in pair bonding in male prairie voles
TLDR
A role for the VTA in partner preference formation in monogamous voles is confirmed and the list of neurochemicals important in pair bonding to include glutamate and GABA is extended.
Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles
TLDR
It is shown here for the first time that MORs modulate partner preference formation in female prairie voles by acting in the CP.
Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles
TLDR
The results demonstrate that oxytocin’s action in the nucleus accumbens is changed through social experience in a way that regulates the trajectory of social interactions as the relationship with the partner unfolds, potentially promoting the maintenance of a pair bond by inhibiting aggressive responses.
Neuropeptide Regulation of Social Attachment: The Prairie Vole Model.
TLDR
The role of OT and AVP in adult mate attachments, biparental care, social isolation, and social buffering as informed by studies utilizing the prairie vole model is discussed, and the implications for human health are discussed.
Oxytocin, vasopressin and pair bonding: implications for autism
  • E. Hammock, L. Young
  • Biology, Medicine
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2006
TLDR
Comparative studies in pair-bonding rodents have revealed neural and genetic mechanisms contributing to social-bond behaviour and generated testable hypotheses regarding the motivational systems and underlying molecular neurobiology involved in social engagement and social bond formation that may have important implications for the core social deficits characterizing autism spectrum disorders.
Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole
TLDR
This is the first study to show that vasopressin neurotransmission occurs in the ventral pallidum during mating, and that V1aR activation in this region is necessary for pair bond formation in male prairie voles.
Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles
TLDR
The role of the central OT system is re-examine in partner preference formation in male prairie voles using a selective OTR antagonist delivered intracranially and results are consistent with the hypothesis that central OTR signaling facilitates social bond formation by coordinating activity across a pair bonding neural network.
Dopamine, oxytocin, and vasopressin receptor binding in the medial prefrontal cortex of monogamous and promiscuous voles
TLDR
The laminar distribution of receptor binding indicates the possibility of an interaction between DA and OT systems in the mPFC in the regulation of social attachment, and differences in D(1)- and D(2)-like receptor binding between species are discussed in terms of how they might modulate cortical activity and subsequent DA release in the nucleus accumbens.
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