Cellular Mechanisms of Normal Growth in the Mammalian Heart: I. Qualitative and Quantitative Features of Ventricular Architecture in the Dog from Birth to Five Months of Age

@article{Legato1979CellularMO,
  title={Cellular Mechanisms of Normal Growth in the Mammalian Heart: I. Qualitative and Quantitative Features of Ventricular Architecture in the Dog from Birth to Five Months of Age},
  author={Marianne J. Legato},
  journal={Circulation Research},
  year={1979},
  volume={44},
  pages={250–262}
}
  • M. Legato
  • Published 1 February 1979
  • Biology
  • Circulation Research
This paper describes the qualitative and quantitative composition of dog myocardium over the first 5 months of life. The quantitative composition of dog right and left ventricle over this period does not vary. A stereological analysis of electron micrographs representing 32,000 Jim* of tissue surface revealed that 79% of the heart is made up of myofibers, whereas 21% is extracellular space. Twenty-eight percent of the extracellular compartment by volume is vasculature (tissue was preserved by… 

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Cellular Mechanisms of Normal Growth in the Mammalian Heart: II. A Quantitative and Qualitative Comparison between the Right and Left Ventricular Myocytes in the Dog from Birth to Five Months of Age

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Not only does myocyte composition change quantitatively, striking changes in intracellular architecture and the appearance and arrangement of intrACEllular organelles occur during postnatal life.

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