Cellular Mechanisms of Normal Growth in the Mammalian Heart: I. Qualitative and Quantitative Features of Ventricular Architecture in the Dog from Birth to Five Months of Age

@article{Legato1979CellularMO,
  title={Cellular Mechanisms of Normal Growth in the Mammalian Heart: I. Qualitative and Quantitative Features of Ventricular Architecture in the Dog from Birth to Five Months of Age},
  author={M. Legato},
  journal={Circulation Research},
  year={1979},
  volume={44},
  pages={250–262}
}
  • M. Legato
  • Published 1979
  • Biology, Medicine
  • Circulation Research
This paper describes the qualitative and quantitative composition of dog myocardium over the first 5 months of life. The quantitative composition of dog right and left ventricle over this period does not vary. A stereological analysis of electron micrographs representing 32,000 Jim* of tissue surface revealed that 79% of the heart is made up of myofibers, whereas 21% is extracellular space. Twenty-eight percent of the extracellular compartment by volume is vasculature (tissue was preserved by… Expand
Cellular Mechanisms of Normal Growth in the Mammalian Heart: II. A Quantitative and Qualitative Comparison between the Right and Left Ventricular Myocytes in the Dog from Birth to Five Months of Age
  • M. Legato
  • Biology, Medicine
  • Circulation research
  • 1979
TLDR
Not only does myocyte composition change quantitatively, striking changes in intracellular architecture and the appearance and arrangement of intrACEllular organelles occur during postnatal life. Expand
Human fetal heart development after mid-term: morphometry and ultrastructural study.
TLDR
Development of the myocyte is an ongoing process which may be continued in the post-natal period in humans, and the statistical results do not support the theory of the right ventricular dominance during the fetal period. Expand
An ultrastructural morphometric study of the papillary muscle of the right ventricle of the cat
TLDR
In a quantitative ultrastructural comparison of perfusion and immersion fixed tissue it was found that significant differences in the volume density of the blood vessel lumen existed between the two groups and a concurrent significant decrease was found for the ratio of mitochondria to myofibrils. Expand
Morphometric Study of Early Postnatal Development in the Left and Right Ventricular Myocardium of the Rat: II. Tissue Composition, Capillary Growth, and Sarcoplasmic Alterations
TLDR
Postnatal myocardial adaptation to the altered work demands on the left and right ventricles shortly after birth resulted in morphological changes that could be the basis for a transient disparity in ventricular functions at about 5 days of age. Expand
Ultrastructural and functional features of the developing mammalian heart: a brief overview.
  • J. Smolich
  • Biology, Medicine
  • Reproduction, fertility, and development
  • 1995
TLDR
Experimental studies in sheep and clinical studies in humans point to marked functional changes during development, which indicate a functional left ventricular dominance rapidly emerges following a postnatal increase in systemic vascular resistance and a decrease in pulmonary vascular resistance. Expand
Characterisation of postnatal growth of the murine heart
TLDR
Using a new technique to isolate rod-shaped cardiomyocytes from small tissue pieces, the first detailed analysis of the phase of so-called developmental hypertrophy is presented, suggesting that the alterations in ventricular morphology in the MLP heart are not due to a general elongation of the cardiomeocytes but to myocyte disarray and ventricular wall thinning caused by the heterogeneous volume of theCardiomyocyte population. Expand
Myocardial capillaries in the fetal and the neonatal rat: a morphometric analysis of the maturing myocardial capillary bed.
Developing myocardial capillaries from 16-day-gestation fetus to adult undergo several morphological changes including a thinning of the lateral extensions of the capillary endothelial cells, theExpand
Morphometric Study of Early Postnatal Development in the Left and Right Ventricular Myocardium of the Rat: I. Hypertrophy, Hyperplasia, and Binucleation of Myocytes
TLDR
It was concluded that, as a result of the circulatory changes occurring shortly after birth, right ventricular growth is analogous to eccentric hypertrophy, whereas left Ventricular growth represents a combination of eccentric and concentrichypertrophy. Expand
Ultrastructural Changes in Postnatal Development of the Cardiac Myocyte
The appearance, distribution, and arrangement of cellular structures in the cardiac myocyte gradually change to give the overall architecture of a mature cell (figure 1–1). Postnatal development isExpand
Ultrastructural Morphometric Analysis of Myocardium from Dogs, Rats, Hamsters, Mice, and from Human Hearts
TLDR
It is concluded that each mammalian species is characterized by a very typical quantitative composition of the myocardium, as well as the morphological correlate of the differing functional capacity of hearts from different species. Expand
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References

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Cellular Mechanisms of Normal Growth in the Mammalian Heart: II. A Quantitative and Qualitative Comparison between the Right and Left Ventricular Myocytes in the Dog from Birth to Five Months of Age
  • M. Legato
  • Biology, Medicine
  • Circulation research
  • 1979
TLDR
Not only does myocyte composition change quantitatively, striking changes in intracellular architecture and the appearance and arrangement of intrACEllular organelles occur during postnatal life. Expand
Normal Growth of Ultrastructures in Rat Left Ventricular Myocardial Cells
TLDR
Normal growth of ultrastructures in left ventricular myocardial cells of rats, ranging in body weight from 36 to 270 g, has been investigated by application of morphometric techniques to light and electron micrographs and suggests that myofibrillar and mitochondrial growth may be controlled. Expand
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Application of mathematical techniques to the study of experimental left ventricular hypertrophy and thyroxin-stimulated growth of myocardial cells has confirmed and extended the results of quantitative measurements on electron micrographs, suggesting that the approaches described can form the basis of a quantitative electron microscopic and microchemical pathology of heart muscle. Expand
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The results suggest that increased work load may induce a further deleterious change in the ratio between mitochondrial units and myofibril units with may lead to decompensation and failure. Expand
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  • Biology, Medicine
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Embryonic chick myocardium (stages 8+ to 12−) was studied by light and electron microscopy and the amount of granular reticulum contained in the myocardial cell cytoplasm is large and suggests that these cells may have a secretory function. Expand
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  • Biology, Medicine
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The embryonicMyocardium displays intense mitotic activity throughout its development and a unique feature of embryonic myocardial cells is the simultaneous occurrence of myofilament synthesis and mitoticactivity within the same cells. Expand
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  • F. Manasek
  • Medicine
  • The American journal of cardiology
  • 1970
Abstract The ultrastructure of the developing chick ventricular myocardium was examined between Hamburger-Hamilton stage 12 − (15 somites; about 45 hours incubation) and the time of hatching (aboutExpand
The ultrastructure of embryonic myocardial blood vessels.
  • F. Manasek
  • Biology, Medicine
  • Developmental biology
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TLDR
Development of ventricular myocardial blood vessels was examined in 7- and 15-day embryonic chicks with the electron microscope, and it was suggested that continued secretion of this material into the lumen is responsible for its subsequent enlargement. Expand
THE APPEARANCE OF GRANULES IN THE GOLGI COMPLEX OF EMBRYONIC CARDIAC MYOCYTES
  • F. Manasek
  • Medicine, Biology
  • The Journal of cell biology
  • 1969
TLDR
Evidence is accumulating that indicates that cardiac muscle has a secretory role in the adult, as well as in the embryo, and both atrial and ventricular muscle cells of the chick contain approximately the same number of secretory granules. Expand
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