Cellular Intrinsic Mechanism Affecting the Outcome of AML Treated with Ara-C in a Syngeneic Mouse Model

@inproceedings{Zhao2014CellularIM,
  title={Cellular Intrinsic Mechanism Affecting the Outcome of AML Treated with Ara-C in a Syngeneic Mouse Model},
  author={Wenjun Zhao and Lirong Wei and Dongming Tan and Guangsong Su and Yanwen Zheng and Chao He and Zhengwei Jenny Mao and Timothy Singleton and B Yin and Linda J Bendall},
  booktitle={PloS one},
  year={2014}
}
The mechanisms underlying acute myeloid leukemia (AML) treatment failure are not clear. Here, we established a mouse model of AML by syngeneic transplantation of BXH-2 derived myeloid leukemic cells and developed an efficacious Ara-C-based regimen for treatment of these mice. We proved that leukemic cell load was correlated with survival. We also… CONTINUE READING